"No official pricing for such therapies has yet been published, but a figure of $649,000 for a one-off treatment has been deemed justifiable for young patients with leukemia by the UK's National Institute for Health and Care Excellence. "Just last week, Kaiser Health News ran a report on the potential pricing of the Novartis version of the therapy, and sources told it that it would 'cost a fortune,' proving to be 'a quantum leap more expensive than other cancer drugs,'" Tech Review notes. The cost to patients, at least in the beginning, could be massive. 29 whether to approve Kite's CAR-T, axi-cel, for treatment of adults with advanced lymphoma.įor MIT's Technology Review, the huge price tag attached to the acquisition is a "clear sign" that Kite's genetic engineering approach to developing cancer therapeutics is the wave of the future.īut there may also be a problem, Tech Review says. Kite Pharma a BUY with a target price of 85.30. If approved, these drugs are expected to generate billions of dollars in profits. Diluted Shares Outstanding 49,624,622 2017 EPS (Est.) -5.67 2016 EPS (Est.) -4.46 2015 EPS -2.33 2014 EPS -1.91. Kite is one of the leading players in the emerging field of CAR-T therapy, and is competing with Novartis, Juno Therapeutics, and Bluebird bio to get the first approved therapy to market, the newswire adds. At $180 a share, that price represents a 29.4 percent premium over Kite's closing share price on Friday, according to Reuters. Gilead Sciences just paid $11.9 billion to acquire Kite Pharma. Advances in Clinical Genomics Profiling.
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doi:10.1016/j.psc.2010.04.005Īpplebaum AJ, Stein EM, Lord-Bessen J, Pessin H, Rosenfeld B, Breitbart W. Cognitive behavioral therapy for mood disorders: Efficacy, moderators and mediators. The development and prediction of athletic performance in freestyle swimming. Stanula A, Maszczyk A, Roczniok R, et al. Optimism and its impact on mental and physical well-being. doi:10.2196/11290Ĭonversano C, Rotondo A, Lensi E, Della vista O, Arpone F, Reda MA. Online positive affect journaling in the improvement of mental distress and well-being in general medical patients with elevated anxiety symptoms: A preliminary randomized controlled trial. Smyth JM, Johnson JA, Auer BJ, Lehman E, Talamo G, Sciamanna CN. Expressive writing: Improving optimism, purpose, and resilience writing and gratitude. The neural basis of optimism and pessimism. Changes in optimism and pessimism in response to life events: Evidence from three large panel studies. Optimism, pessimism and mental health: A twin/adoption analysis. Plomin R, Scheier MF, Bergeman CS, Pedersen NL, Nesselroade JR, McClearn GE. One study found that expressive writing focused on positive emotions was linked to decreased mental distress and improved mental well-being. Write down your positive emotions: Research has shown that something as simple as writing down positive thoughts can help improve your optimism. If you are trying to develop a more optimistic attitude, set aside a few minutes each day to jot down some of the things for which you are grateful. One study found that participants who were assigned to write in a gratitude journal showed increased optimism and resilience. Practice gratitude: Gratitude can be defined as an appreciation for what is important in life.This allows you to feel more appreciative of what you have now and less consumed with regrets and anxieties. If you are living fully in the moment, you are much less likely to ruminate over negative past experiences or worry about upcoming events. Become more mindful: Mindfulness is a focus on being engaged, attentive, and present in the here and now. It can be a useful technique to help you focus on what matters in the present and avoid worrying about future events and things that are outside of your control. MagiQuest is an immersive game experience that takes you on a magical adventure. Paw’s kin’ll give you the tools you’re gonna need to do the job. When youre seeking the perfect family escape, our resort has you covered. Can You Survive The Craft family has a twisted tradition. Ya best be hurryin’ cause Maw will be back soon. The captured is an interactive live escape game (a game in which people are locked in a room with other participants and have to use elements of the room to solve a series of puzzles, find clues, and escape) located at the base of the Gatlinburg Space Needle. It’s time to defend that family honor which’n no one quite understands and put Maw outta’ business fer good. No one would ever suspect them fancy city folk is really Paw’s seventh cousins five times removed. The game capacity for each game is listed within the online booking platform.For years Paw and Maw had been runnin’ neck and jiggly neck with each other but Maw reckons she might could have a new secret recipe so good it’ll put hair on your chest and Paw outta’ business for good -and you can bet Paw ain’t havin’ none of neither! She’s fixin’ to hold a hootenanny tonight to celebrate the launch of her new brew, so there ain’t much tickin’ and a tockin’ left on the old time wheel for Paw to stop ‘er before it’s too late.Įven a blind toad that ain’t got but just three legs can see that’s where you come in. (865) groups can also book themselves using the online booking platform on this page. Groups that require multiple rooms often book through our Guest Experience Team. **Important**: please call us before making your reservation so that we can add their spot to your reservation, due to each game having a maximum capacity for players. Children age 4 and under can come along with you free of charge. Any participants under the age of 18 will need an adult to sign their waiver. Book your Escape Room in Gatlinburg, TN and find out for yourself (865) 412-8574. Can you perform unbelievable feats and become one of the Masters of Magic 634 Parkway, Gatlinburg, TN 37738. A paying adult, 18 or older, must participate with anyone that is 14 and under. Begin in Reflecto’s dressing room, then progress throughout the backstage areas of a historic performance theater, and if talented enough, eventually into the secret Realm of Illusions. We do allow younger players, but some of the game content may be too difficult for them. We recommend our games for ages 13 and up. If you are having any problems using your gift card(s), please call us and a team member will be happy to assist you!.You'll receive a confirmation email for each card you use.Multiple gift cards cannot be applied to one reservation please give us a call to book your game.Enter this code in the "Have a promo code?" tab on the payment page. Each gift card has a unique 13-digit code. Your gift card will be used to book your adventure, so make sure it's handy when you make your reservation. Within 4 hours of the start time, the game is not transferable and non-refundable.Įach gift card is valid for one player in one game. We understand that plans change, so reservations can be canceled up to 48 hours before your game for a full refund! We can reschedule games up to 4 hours before your reservation time. To view those games, click to the next day. We often offer games that start after midnight. If the available spots do not match the game capacity, that means another group has already booked spots in this game. If you would like to ensure a private experience make sure to book all available spots. We offer shared experiences, which means multiple groups can book into the same game. If a film is directed by siblings, you know you’re in for a good ride – just look at the work of the Coens (Fargo), the Wachowskis (The Matrix) or the Safdies (Uncut Gems). The hosts are entertaining, but the premise offputtingly vacuous. Their dive into African wealth means various meetings with multi-millionaire fashion designers and Afrobeats megastars. The comedian has owned the set since childhood, but has since donated it to a local museum the pair talk movingly about how hobbies such as these can help distract from grief.Ĭomedians Eddie Kadi and Guz Khan take a tour of Accra, Ghana’s glitzy capital which has become a playground for the “one per cent”. The retired music producer and train enthusiast travels to Bexhill-on-Sea, where he takes in the miniature delights of Eddie Izzard’s model railway. Little Trains & Big Names with Pete Waterman The case presents a challenge for bookish young vet Carmody (James Anthony-Rose), whose bedside manner needs some serious work, and an unexpected threat for the newly pregnant Helen (Rachel Shenton). Domestic bliss does not last for long, however, as Claudia begins to have a bloodthirsty post-life crisis about the prospect of being 18 forever.Ī mysterious illness is ripping through the animals of a local farm, threatening everything the novice owners have built. The raunchy gothic-horror trades sex for family drama this week, as Louis (Jacob Anderson) and Lestat (Sam Reid) take on the role of guardians to young fledgling vampire Claudia (Bailey Bass). His defence is that he prefers post-work pints to ironing shirts. One recruit who will not be joining them is Private Curtis Dryden, who has been declared absent without leave. The platoon face their greatest challenge yet this week: a combat exercise in which the rookies must fight highly trained Gurkhas. In the first episode of this new series, which will spotlight a different director every week, critic Ian Nathan breaks down what makes films such as Black Narcissus and The Red Shoes the sublime classics that they are today. Powell and Pressburger are one of the all-time great film-making partnerships. He wants to put more black people both in front of and behind the camera. As Sir Lenny says, however, he is not interested in maintaining the status quo. Yet through his work as the co-founder of Comic Relief, he was able to channel that anarchic spirit into something with mass appeal. As one of the few black faces on mainstream television during the 1970s and 1980s, his very presence was subversive – and that’s before you consider sketch characters such as the sexually aggressive soul singer Theophilus P Wildebeeste, which Henry admits wouldn’t fly today. It is your classic puff piece, but at least Henry deserves it.īen Elton describes Henry as “mainstream alternative”, which feels apt. “I can’t imagine not liking Lenny Henry,” says David Tennant, who joins the likes of Richard Curtis, Trevor McDonald and Whoopi Goldberg in rhapsodising his achievements. Following the ITV1 premiere of his drama Three Little Birds on Sunday, this starry retrospective charts the comedian’s rise from working-class child of Jamaican immigrants to national treasure. There are few careers in British television as interesting, or as influential, as Lenny Henry’s. The end result? As the show puts it, in tongue-in-cheek fashion: "The work, which becomes a new genre itself, will be called… Cowboy Bebop." The show’s legendary 26-episode run fuses creator Hajime Yatate’s effortless eye for action with composer Yoko Kanno’s kinetic jazz soundtrack. “There’s this other crazy energy that’s about to turn things upside down.The short-lived Netflix live-action series may have soured some on the property, but there’s a reason why Cowboy Bebop is almost always seen as shorthand for ‘classic anime.’ “That final moment with Ed was a reminder that things will go on,” said Nemec. So why was the Radical Edward cameo included at all? Because Nemec thought it was important to cut the heaviness of the finale - to “leave everybody with a little bit of a smile on their face, versus the tragedy. “So that meant saving Radical Ed for a second season, fingers crossed, where we really get to tell Ed’s story.” “There’s a lot to mine out of Radical Ed and who she is, what she is, where she comes from why she does what she does,” said Nemec. Nemec said there wasn’t enough time to properly introduce Radical Edward during “Cowboy Bebop’s” first season. Because she “will only spin more chaos into the group.” “It felt important to me to really be able to mine the characters of Spike and Jet and Faye, to really cement the crew of the Bebop, and get to know who these people are before dropping the Ed atom bomb on them,” said Nemec. But she also helps strengthen their bond, and her skills become invaluable to the team. Her full name, at least in the anime, is Edward Wong Hau Pepelu Tivruski IV.Įd’s introduction in the anime disrupts the Bebop crew’s established dynamic. In the anime, Ed is the fourth crewmember of the Bebop and joins the team in the ninth episode. That character is Radical Edward (Eden Perkins), a brilliant young hacker who was briefly mentioned earlier in the series. What’s with the kid who finds Spike at the very end? Introducing newcomer Eden Perkins (they/them), who plays the role of Radical Ed in Netflix’s COWBOY BEBOP, now streaming /ttnL7xdTVb- Netflix Geeked November 19, 2021 To everyone who’s been asking “Where’s Ed?” - you don’t have to wait any longer His thoughts are frozen in time and hers are absolutely not.” And I think it speaks volumes to Spike’s character, to the romantic ideas that float through his head and to the dreams that he has from the very beginning, that he still longs for something that he hasn’t allowed to evolve. “She shoots him out the window and to me it feels very justified in that moment,” said Nemec. Nemec realized it was important for Julia to ask Spike why he had never gone back for her: From her perspective, he just abandoned her to a life with Vicious. “I knew that I wanted Julia to shoot Vicious.”īut if Julia’s reason for shooting Vicious was clear from the get-go, the reason for her shooting Spike came later, as Nemec and the writers room considered Julia and Spike’s reunion. “I knew that I wanted Julia to show up to the cathedral,” said Nemec. We surveyed The Times TV team to come up with a list of the 75 best TV shows you can watch on Netflix. Television The 75 best TV shows on Netflix right now, according to our experts Here is a breakdown of some of the key elements from the “Cowboy Bebop” finale that sets it apart from the story told in the original show. “To see this woman - who has been put into this environment and, through her desire to escape the environment, inculcated into its horror, into its violence - realize that take the reins now.” “The more we talked about in the writers room, the more it became clear that we had this amazing opportunity to birth a villain,” said “Cowboy Bebop” showrunner and executive producer André Nemec. This arc, unique to the live-action series, is one of the biggest changes it makes from the anime. This is especially apparent in the season finale, which culminates with Julia’s (Elena Satine) transformation into a full-on villain. Starring John Cho, Mustafa Shakir and Daniella Pineda as the cowboys of the spaceship Bebop, the new adaptation layers familiar characters, moments, visuals, sounds and other references from the anime with its own unique narrative that - while spiritually faithful to the anime - diverges at times from the story told in the original show. Netflix’s live-action “Cowboy Bebop” series is akin to a new arrangement of the opus that is the beloved original anime series. This story discusses details from the Season 1 finale of Netflix’s “Cowboy Bebop.” If you have yet to watch the season, consider this feature about how the live-action adaptation is different from the anime. If the other testicle was injured, both of her eyes were gouged out. If a woman in a quarrel injured a man’s testicle, her finger was cut off. He writes, “In fact, Middle Assyrian laws (around 1100 BC) present a similar scenario (in the case of injury to the man), though with far more drastic consequences. However, Copan also points out that this law was still ahead of the ANE at the time. It seems nearly just as bad (and ultimately more bizarre!). He makes a linguistic argument for this, but I don’t find this much better than the plain sense reading. Indeed, two presidents, Teddy Roosevelt and John Quincy Adams, did not use a. So, this was treated very seriously.Ĭopan argues that the Hebrew in this verse is actually referring to publicly shaving the woman’s pubic hair! That is, the woman was to be publicly humiliated for her actions. Placing a hand on a Bible while reciting the presidential oath is simply a tradition started by George Washington. If the man had his testicles crushed, this would not only be exceedingly painful (!!), but he would lose a stake in the community of Israel (Deut. Joyce Meyer Ministries exists to share Christ through daily TV shows, podcasts, devotionals, bible study and conference events and love people through Hand. crushing a man’s testicles) that the law told them to cut her hand off before she could cause the man harm. The text never says that the woman crushes the man’s genitals-only that she grabs them. This might be the prevention of harm, rather than the retribution of harm. It might be similar to a SWAT sniper shooting someone with a hostage. RESPONSE: This is probably referring to justice “on the spot,” rather than later. 25:11-12) Why were women’s hands cut off for grabbing a man’s genitals?ĬLAIM: Moses explains, “If two men are fighting and the wife of one of them comes to rescue her husband from his assailant, and she reaches out and seizes him by his private parts, 12 you shall cut off her hand. Important: As soon as a picture or file is accidentally deleted, or you discover any missing, do NOT save any more pictures or files to that memory device or hard disk drive otherwise you may overwrite your lost data. PhotoRec is a companion program to TestDisk, an application for recovering lost partitions on a wide variety of file systems and making non-bootable disks bootable again.įor more safety, PhotoRec uses read-only access to handle the drive or memory card you are about to recover lost data from. PhotoRec is free - this open source multi-platform application is distributed under GNU General Public License (GPLV v2+). PhotoRec ignores the file system and goes after the underlying data, so it will still work even if your media's file system has been severely damaged or reformatted. PhotoRec is file data recovery software designed to recover lost files including video, documents and archives from hard disks (Mechanical Hard drives, Solid State Drives.), CD-ROMs, and lost pictures (thus the Photo Recovery name) from digital camera memory. Nearly 400,000 subscribers received the newsletter complete with a handwritten tip every day.PhotoRec, Digital Picture and File Recovery He gave advice on dark web scans on Miami's NBC 6, discussed Windows XP's demise on WGN-TV's Midday News in Chicago, and shared his CES experiences on WJR-AM's Guy Gordon Show in Detroit.Ĭhris also ran MakeUseOf's email newsletter for two years. In addition to his extensive writing experience, Chris has been interviewed as a technology expert on TV news and radio shows. The company's project was later reportedly shut down by the U.S. A wave of negative publicity ensued, with coverage on BuzzFeed News, CNBC, the BBC, and TechCrunch. At CES 2018, he broke the news about Kodak's "KashMiner" Bitcoin mining scheme with a viral tweet. Starting in 2015, Chris attended the Computer Electronics Show (CES) in Las Vegas for five years running. His work has even appeared on the front page of Reddit.Īrticles he's written have been used as a source for everything from books like Team Human by Douglas Rushkoff, media theory professor at the City University of New York's Queens College and CNN contributor, to university textbooks and even late-night TV shows like Comedy Central's with Chris Hardwick. His roundups of new features in Windows 10 updates have been called "the most detailed, useful Windows version previews of anyone on the web" and covered by prominent Windows journalists like Paul Thurrott and Mary Jo Foley on TWiT's Windows Weekly. Instructional tutorials he's written have been linked to by organizations like The New York Times, Wirecutter, Lifehacker, the BBC, CNET, Ars Technica, and John Gruber's Daring Fireball. The news he's broken has been covered by outlets like the BBC, The Verge, Slate, Gizmodo, Engadget, TechCrunch, Digital Trends, ZDNet, The Next Web, and Techmeme. Beyond the column, he wrote about everything from Windows to tech travel tips. He founded PCWorld's "World Beyond Windows" column, which covered the latest developments in open-source operating systems like Linux and Chrome OS. He also wrote the USA's most-saved article of 2021, according to Pocket.Ĭhris was a PCWorld columnist for two years. Beyond the web, his work has appeared in the print edition of The New York Times (September 9, 2019) and in PCWorld's print magazines, specifically in the August 2013 and July 2013 editions, where his story was on the cover. With over a decade of writing experience in the field of technology, Chris has written for a variety of publications including The New York Times, Reader's Digest, IDG's PCWorld, Digital Trends, and MakeUseOf. Chris has personally written over 2,000 articles that have been read more than one billion times-and that's just here at How-To Geek. Chris Hoffman is the former Editor-in-Chief of How-To Geek. Illustrator is great if you currently use many Adobe Creative Cloud applications. Overall, both Affinity Designer and Adobe Illustrator are powerful vector-based programs. While vector drawing can be an alien topic to most, you will be an expert in no time by following tutorials. Both Adobe Illustrator and Affinity Designer have resources to guide you through the world of vector graphics. Affinity Designer and Adobe Illustrator are powerful programs that create great vector graphics, designing professional-level results. Both programs are used by hobbyists and professionals alike. Affinity Designer sticks closer to the essentials, leaving the interface more intuitive and less cluttered. This program, while still requiring a bit of learning, is easier to use than Adobe Illustrator. Both programs have limitations when trying to use their native files in other programs. Adobe Illustrator and Affinity Designer are compatible with both Mac and Windows users. While a full Affinity suite may be a giant competitor to Adobe in the future, right now, Adobe is still the ubiquitous family of software in the creative professional world. Adobe Illustrator has been the industry standard for decades. Affinity Designer is available as a one-time purchase of $49.99. Adobe Illustrator is only offered in a subscription-based model, the lowest price being $20.99/month. The software has more specialized tools, helping expert designers perfect their work. Overall, Adobe Illustrator has more tools than Affinity Designer. And I can't see that with V2.If you’re in a hurry, see the summary of the comparison below. But it needs a more solid core of functionalities in order to get there. I believe firmly that Affinity is in the lead to cap this market. With an " Adobe Reputation" and with comfortable prices for hobbyists as well as professionals and a bit of marketing, the Sales VOLUME of Affinity has the potential to explode! There's a huge market tired of the Adobe Extortion, waiting for something new, better and much cheaper. The fact that you don't buy, but rather just rent Adobe Software and the discrimination against European Customers all are points that don't sit well, even with profssionals. I know there has been A LOT of grumblings about Adobe's insane prices in photo and graphics fora I'm following. But inching ever closer to Adobe in functionalities and keeping retail prices down could potentially torpedo Adobe. It's hard as a user to judge how much such functionalities would influence the price in a negative way. So, it beggars belief that it is still not included in Affinity Designer 2, Affinity Photo 2 and Affinity Publisher 2. That's abuse of privilege and it has moved me to chuck Adobe overboard!īut still, an AutoTrace function is yesterday's technology in this scope, really. But it's VASTLY overpriced software, which even slaps on a 50% increase in the price for European users, and you don't even get to own the damn thing. And to be able to stay at this user's comfort prices, with good and at times great Software, we cannot expect everything. Will Affinity continue to be competitive with ever new graphics capabilities following new Softwares, Hardwares and even AI?Īffinity is affordable for hobbyists as well as professionals. I can't see any (significant) difference in Inpainting, Background Removal and such from V1.Īnd since this is tangential to the Algorithms used in AutoTrace, converting Bitmap into Vector, the question should be asked I'm not too impressed with the image recognition functionalities in Affinity Photo V2 either. But it's a lot of back and forth, potential security issues and general nuisance. Sure, you can do it online, with mixed results. It's such a bummer that this relatively simple, yet essential functionality is still not onboard in Affinity Designer V2. The ragdoll physics mechanism will both apply to vehicles and drivers so that players will have more options in colliding with other drivers or the environment. Players will gain more points if they complete these mini-games, even more than reaching the first place in a short time. What makes the gameplay of the game stand out is the ragdoll physics element, along with countless mini-games that appear on the track. Since then, bring many new experiences with attractive features suitable for this environment. Moreover, compared to its previous game, this time, it had a race track designed in the city environment. Players will have more options when choosing vehicles because each track includes a variety of terrain and corner types for players to enjoy. The game classifies cars into three categories, namely derby, race, and street, with a variety of features and performance. The base gameplay of FlatOut 2 is still an arcade action racing game, and players will participate in bustling races with whatever means they want. Players will not only enjoy a tense atmosphere of the races but will focus on entertainment by hitting the bumps, the environment, and the other riders. What makes the second game of the series stand out is the ragdoll physics mechanism applied to the driver. But not for this series, because the player has many goals bigger than reaching the first place. Racing games often have similar gameplay, which is to use the vehicles available in the game to complete the race in the first place. Neo Bomberman for the Neo Geo arcade console is the subject of this guide.FlatOut is the most innovative racing game series that has ever appeared on various platforms, and FlatOut 2 is the second game in the series with many dizzying and appealing improvements compared to the previous game. Neo Bomberman was created to help players take advantage of the amazing experience of playing this amazing game on the Neo Geo arcade console.ĭownload our guide to Neo Bomberman, the most popular arcade game for the Neogeo console. Hudson Soft developed the Neo Geo version of Neo Bomberman alongside Panic Bomber, and both titles were released for the hardware. Contrary to Panic Bomber, Neo Bomberman looks from above, rather than from the sides. Exclusively for the Neo Geo MVS, the game was not released on other home consoles. The creator of the game or any of the licensees are not affiliated with this unofficial version. This application complies with fair use guidelines according to U.S. The names, images, characters, logos, and other features of the diversions were not made by us. The law of the United States establishes reasonable use guidelines for this application,Īnd we welcome direct contact from you if you believe there is an immediate infringement of your trademark or copyright. There are many new features in the new version, some of which are similar to those in previous versions. I will share the new and old versions of this tool. What are the advantages and disadvantages of downloading Neo Bomberman APK directly? Positives: Users will find the interface easy to use.Your comments in a comment section can also be shared with others. I've been using Discordant Chorus a while mostly because it just procs SO MUCH and even if damage weren't significant I figured it helps with snagging agro during my wild pulls (plus visual is sweet). Though I was familiar with most of the info here I really appreciate the info on trinkets, plus glad to see some confirmation on many of my choices. For better or worse I took an 8 year break and missed out on the MoP and WoD legendaries but managing well enough. as holy! Sometimes I just go shadow anyway (looking at you Caverns of Time) since my dps is so strong and can get away with occasional Shadow Mend depending on tank. My priest is not quite so exciting but can lead many groups on single target dps. Pulls are often "everything up to the next boss. She's pretty decked out in 5str/6sta gems and in most groups she is >50% of groups total damage and Word of Glory does is basically a repeatable LOH. I only recently starting doing timewalking and now it's one of my favorite things, especially on my prot paladin that absolutely goes off. Get Wowhead Premium $2 A Month Enjoy an ad-free experience, unlock premium features, & support the site!Ĭomment by nyalriaAwesome guide. You can also message me on Discord if you have any questions. If you have any questions come join our discord Miscellaneous items: items with high stat budget, items with special effects etc.STR DPS / Tanks: Gong-Lu, Strength of XuenĪll specs Ashjra'kamas, Shroud of Resolve MoP Legendary Cloaks or Rank 12 BFA Legendary Cloak:Ĭasters / Healers: Xing-Ho, Breath of Yu'lon.Heart of Azeroth & Azerite Gear / Current Tier Sets.Structure of Timewalking set & Core Items Speedrunning Dungeons / Raids, pushing gear, and specs to their limits.Gearing up for Timewalking can be fun for some people.
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